Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics

In the present study we aimed to identify novel mechanisms and therapeutics for thoracic aortic aneurysm (TAA) in Fbn1(C1039G/+) Marfan Syndrome (MFS) mice. The expression of mature/active TGFβ and its downstream effector NOX4 were upregulated while tetrahydrobiopterin (H(4)B) salvage enzyme dihydro...

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Detalles Bibliográficos
Autores principales: Huang, Kai, Wang, Yongchen, Siu, Kin Lung, Zhang, Yixuan, Cai, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585948/
https://www.ncbi.nlm.nih.gov/pubmed/33126053
http://dx.doi.org/10.1016/j.redox.2020.101757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585948/
https://www.ncbi.nlm.nih.gov/pubmed/33126053
http://dx.doi.org/10.1016/j.redox.2020.101757

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