SHC014748M, a novel selective inhi-bitor of PI3Kδ, demonstrates promising preclinical antitumor activity in B cell lymphomas and chronic lymphocytic leukemia

PI3Kδ (phosphatidylinositol 3-kinase-δ), one of the class I PI3Ks, is found expressed primarily in leukocytes and plays an essential role in B-cell development and function. This provides a rationale for the development of small molecule inhibitors that selectively target p110δ for patients with ind...

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Detalles Bibliográficos
Autores principales: Fan, Lei, Wang, Chao, Zhao, Liwen, Wang, Zhiqiang, Zhang, Xian, Liu, Xiaorong, Cao, Lei, Xu, Wei, Li, Jianyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586065/
https://www.ncbi.nlm.nih.gov/pubmed/33142237
http://dx.doi.org/10.1016/j.neo.2020.10.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586065/
https://www.ncbi.nlm.nih.gov/pubmed/33142237
http://dx.doi.org/10.1016/j.neo.2020.10.004

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