Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

There is increasing evidence for a role of inflammation in Parkinson’s disease. Recent research in murine models suggests that parkin and PINK1 deficiency leads to impaired mitophagy, which causes the release of mitochondrial DNA (mtDNA), thereby triggering inflammation. Specifically, the CGAS (cycl...

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Detalles Bibliográficos
Autores principales: Borsche, Max, König, Inke R, Delcambre, Sylvie, Petrucci, Simona, Balck, Alexander, Brüggemann, Norbert, Zimprich, Alexander, Wasner, Kobi, Pereira, Sandro L, Avenali, Micol, Deuschle, Christian, Badanjak, Katja, Ghelfi, Jenny, Gasser, Thomas, Kasten, Meike, Rosenstiel, Philip, Lohmann, Katja, Brockmann, Kathrin, Valente, Enza Maria, Youle, Richard J, Grünewald, Anne, Klein, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586086/
https://www.ncbi.nlm.nih.gov/pubmed/33029617
http://dx.doi.org/10.1093/brain/awaa246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586086/
https://www.ncbi.nlm.nih.gov/pubmed/33029617
http://dx.doi.org/10.1093/brain/awaa246

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