Cargando…

Lung Carcinoma Cells Secrete Exosomal MALAT1 to Inhibit Dendritic Cell Phagocytosis, Inflammatory Response, Costimulatory Molecule Expression and Promote Dendritic Cell Autophagy via AKT/mTOR Pathway

OBJECTIVE: To investigate the potential mechanism underlying the effect of lung carcinoma cell-derived exosomes on dendritic cell function. MATERIALS AND METHODS: C57BL/6 (B6) mice were randomly divided into five groups: control, dendritic cell (DC), DC-NC, DC-siMALAT1, and siMALAT1. Tumor cell prol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yanyan, Yin, Zhucheng, Lu, Ping, Ma, Yifei, Luo, Bo, Xiang, Lanxin, Zhang, Wangli, He, Yu, Liang, Xinjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586126/ https://www.ncbi.nlm.nih.gov/pubmed/33116646 http://dx.doi.org/10.2147/OTT.S256669

Ejemplares similares

Peripheral Polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection in non‐small cell lung cancer
por: Liu, Yanyan, et al.
Publicado: (2022)

mTOR inhibitors effects on regulatory T cells and on dendritic cells
por: Stallone, Giovanni, et al.
Publicado: (2016)

Costimulatory Molecules on Immunogenic Versus Tolerogenic Human Dendritic Cells
por: Hubo, Mario, et al.
Publicado: (2013)

Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling
por: Xu, Jing, et al.
Publicado: (2019)

Dendrite pathology and neurodegeneration: focus on mTOR
por: Di Polo, Adriana
Publicado: (2015)

Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells
por: Carenza, Claudia, et al.
Publicado: (2019)

mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells
por: Saric, Amra, et al.
Publicado: (2016)

Regulation of RLR-Mediated Antiviral Responses of Human Dendritic Cells by mTOR
por: Fekete, Tünde, et al.
Publicado: (2020)

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
por: Tseng, Su-Yi, et al.
Publicado: (2001)

Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus
por: Colonna, Lucrezia, et al.
Publicado: (2006)

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations
Publicado: (1992)

Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin
por: Borg, Rachael J., et al.
Publicado: (2015)

Selenoprotein K Is Essential for the Migration and Phagocytosis of Immature Dendritic Cells
por: Xia, Huan, et al.
Publicado: (2022)

Loss of exosomal MALAT1 from ox-LDL-treated vascular endothelial cells induces maturation of dendritic cells in atherosclerosis development
por: Li, Hongqi, et al.
Publicado: (2019)

Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway
por: van Montfort, Thijs, et al.
Publicado: (2019)

Itaconate attenuates autoimmune hepatitis via PI3K/AKT/mTOR pathway-mediated inhibition of dendritic cell maturation and autophagy
por: Zhang, Qiyu, et al.
Publicado: (2023)

Argon Plasma Exposure Augments Costimulatory Ligands and Cytokine Release in Human Monocyte-Derived Dendritic Cells
por: Bekeschus, Sander, et al.
Publicado: (2021)

circ_0004140 promotes LUAD tumor progression and immune resistance through circ_0004140/miR-1184/CCL22 axis
por: Liu, Yanyan, et al.
Publicado: (2022)

LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent mTOR signalling
por: Scheffler, Julia M., et al.
Publicado: (2014)

Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation
por: Cheng, Mengmeng, et al.
Publicado: (2016)

Properties of immature and mature dendritic cells: phenotype, morphology, phagocytosis, and migration
por: Kim, Min Kyung, et al.
Publicado: (2019)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Dendritic Cell-Derived Exosomes in Cancer Immunotherapy
por: Luo, Shumin, et al.
Publicado: (2023)

Correction: Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation
por: Cheng, Mengmeng, et al.
Publicado: (2018)

Regulation of Dendritic Cell Immune Function and Metabolism by Cellular Nutrient Sensor Mammalian Target of Rapamycin (mTOR)
por: Snyder, Julia P., et al.
Publicado: (2019)

Pathogens MenTORing Macrophages and Dendritic Cells: Manipulation of mTOR and Cellular Metabolism to Promote Immune Escape
por: Nouwen, Lonneke V., et al.
Publicado: (2020)

HMGB1 Activates Myeloid Dendritic Cells by Up-Regulating mTOR Pathway in Systemic Lupus Erythematosus
por: Song, Xinghui, et al.
Publicado: (2021)

lncRNA Malat1 modulates the maturation process, cytokine secretion and apoptosis in airway epithelial cell-conditioned dendritic cells
por: Li, Zhoubin, et al.
Publicado: (2018)

Myeloid dendritic cells in severe aplastic anemia patients exhibit stronger phagocytosis
por: Sun, Yingying, et al.
Publicado: (2021)

Plasmodium Infection–Cure Cycles Increase the Capacity of Phagocytosis in Conventional Dendritic Cells
por: Adachi, Ryosuke, et al.
Publicado: (2023)

HMGB1/PI3K/Akt/mTOR Signaling Participates in the Pathological Process of Acute Lung Injury by Regulating the Maturation and Function of Dendritic Cells
por: Li, Ruiting, et al.
Publicado: (2020)

mTOR-Myc axis drives acinar-to-dendritic cell transition and the CD4(+) T cell immune response in acute pancreatitis
por: Xu, Dan, et al.
Publicado: (2020)

Kinetic Changes in B7 Costimulatory Molecules and IRF4 Expression in Human Dendritic Cells during LPS Exposure
por: Velazquez-Soto, Henry, et al.
Publicado: (2022)

Weakened IL-15 Production and Impaired mTOR Activation Alter Dendritic Epidermal T Cell Homeostasis in Diabetic Mice
por: Liu, Zhongyang, et al.
Publicado: (2017)

Cardiac progenitor cell-derived exosomes promote H9C2 cell growth via Akt/mTOR activation
por: Li, Shentang, et al.
Publicado: (2018)

The AMPK-mTOR axis requires increased MALAT1 expression for promoting granulosa cell proliferation in endometriosis
por: Liu, Xuejie, et al.
Publicado: (2021)

Phagocytosis of Enterovirus-Infected Pancreatic β-Cells Triggers Innate Immune Responses in Human Dendritic Cells
por: Schulte, Barbara M., et al.
Publicado: (2010)

Poly(ethylene glycol)-Lipid-Conjugated Antibodies Enhance Dendritic Cell Phagocytosis of Apoptotic Cancer Cells
por: Tomita, Urara, et al.
Publicado: (2012)

Porphyromonas gingivalis Provokes Exosome Secretion and Paracrine Immune Senescence in Bystander Dendritic Cells
por: Elsayed, Ranya, et al.
Publicado: (2021)

Modulation of the mTOR pathway plays a central role in dendritic cell functions after Echinococcus granulosus antigen recognition
por: Rodriguez Rodrigues, Christian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ldjg7pn1eg71mjvc57lihpeqla