Intra‐gastrointestinal amyloid‐β1–42 oligomers perturb enteric function and induce Alzheimer's disease pathology

KEY POINTS: Alzheimer's disease (AD) patients and transgenic mice have beta‐amyloid (Aβ) aggregation in the gastrointestinal (GI) tract. It is possible that Aβ from the periphery contributes to the load of Aβ in the brain, as Aβ has prion‐like properties. The present investigations demonstrate...

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Detalles Bibliográficos
Autores principales: Sun, Yayi, Sommerville, Nerina R., Liu, Julia Yuen Hang, Ngan, Man Piu, Poon, Daniel, Ponomarev, Eugene D., Lu, Zengbing, Kung, Jeng S. C., Rudd, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Alimentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586845/
https://www.ncbi.nlm.nih.gov/pubmed/32617993
http://dx.doi.org/10.1113/JP279919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586845/
https://www.ncbi.nlm.nih.gov/pubmed/32617993
http://dx.doi.org/10.1113/JP279919

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