Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains

Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2‐electron reduction of the enzyme‐bound thioester releasing the generated peptides as C‐terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from an aldehyde‐generating minimal NRPS termed AT...

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Detalles Bibliográficos
Autores principales: Tietze, Andreas, Shi, Yan‐Ni, Kronenwerth, Max, Bode, Helge B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586950/
https://www.ncbi.nlm.nih.gov/pubmed/32378773
http://dx.doi.org/10.1002/cbic.202000176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586950/
https://www.ncbi.nlm.nih.gov/pubmed/32378773
http://dx.doi.org/10.1002/cbic.202000176

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