Sacubitrilat reduces pro‐arrhythmogenic sarcoplasmic reticulum Ca(2+) leak in human ventricular cardiomyocytes of patients with end‐stage heart failure

AIMS: Inhibition of neprilysin and angiotensin II receptor by sacubitril/valsartan (Val) (LCZ696) reduces mortality in heart failure (HF) patients compared with sole inhibition of renin–angiotensin system. Beneficial effects of increased natriuretic peptide levels upon neprilysin inhibition have bee...

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Detalles Bibliográficos
Autores principales: Eiringhaus, Jörg, Wünsche, Christoph M., Tirilomis, Petros, Herting, Jonas, Bork, Nadja, Nikolaev, Viacheslav O., Hasenfuss, Gerd, Sossalla, Samuel, Fischer, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586991/
https://www.ncbi.nlm.nih.gov/pubmed/32710603
http://dx.doi.org/10.1002/ehf2.12918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586991/
https://www.ncbi.nlm.nih.gov/pubmed/32710603
http://dx.doi.org/10.1002/ehf2.12918

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