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Genome‐wide off‐rates reveal how DNA binding dynamics shape transcription factor function

Protein–DNA interactions are dynamic, and these dynamics are an important aspect of chromatin‐associated processes such as transcription or replication. Due to a lack of methods to study on‐ and off‐rates across entire genomes, protein–DNA interaction dynamics have not been studied extensively. Here...

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Detalles Bibliográficos
Autores principales: de Jonge, Wim J, Brok, Mariël, Lijnzaad, Philip, Kemmeren, Patrick, Holstege, Frank CP
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586999/
https://www.ncbi.nlm.nih.gov/pubmed/33280256
http://dx.doi.org/10.15252/msb.20209885