New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition

A novel series of zileuton-hydroxycinnamic acid hybrids were synthesized and screened as 5-lipoxygenase (5-LO) inhibitors in stimulated HEK293 cells and polymorphonuclear leukocytes (PMNL). Zileuton’s (1) benzo[b]thiophene and hydroxyurea subunits combined with hydroxycinnamic acid esters’ ester lin...

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Detalles Bibliográficos
Autores principales: Chiasson, Audrey Isabel, Robichaud, Samuel, Ndongou Moutombi, Fanta J., Hébert, Mathieu P. A., Mbarik, Maroua, Surette, Marc E., Touaibia, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587396/
https://www.ncbi.nlm.nih.gov/pubmed/33066378
http://dx.doi.org/10.3390/molecules25204686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587396/
https://www.ncbi.nlm.nih.gov/pubmed/33066378
http://dx.doi.org/10.3390/molecules25204686

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