Cargando…

New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition

A novel series of zileuton-hydroxycinnamic acid hybrids were synthesized and screened as 5-lipoxygenase (5-LO) inhibitors in stimulated HEK293 cells and polymorphonuclear leukocytes (PMNL). Zileuton’s (1) benzo[b]thiophene and hydroxyurea subunits combined with hydroxycinnamic acid esters’ ester lin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chiasson, Audrey Isabel, Robichaud, Samuel, Ndongou Moutombi, Fanta J., Hébert, Mathieu P. A., Mbarik, Maroua, Surette, Marc E., Touaibia, Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587396/ https://www.ncbi.nlm.nih.gov/pubmed/33066378 http://dx.doi.org/10.3390/molecules25204686

Ejemplares similares

Extraction, Antioxidant Capacity, 5-Lipoxygenase Inhibition, and Phytochemical Composition of Propolis from Eastern Canada
por: Sambou, Mariama, et al.
Publicado: (2020)

Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5‐lipoxygenase and stability in human blood and HepaRG cells
por: Mbarik, Maroua, et al.
Publicado: (2019)

New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis
por: Boudreau, Luc H., et al.
Publicado: (2017)

Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction
por: Abueid, Leyla, et al.
Publicado: (2017)

Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation
por: Gounaris, Elias, et al.
Publicado: (2015)

The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARα
por: Wu, Qing-Qing, et al.
Publicado: (2019)

Inhibition of 5-lipoxygenase inhibitor zileuton in high-fat diet-induced nonalcoholic fatty liver disease progression model
por: Ma, Kuifen, et al.
Publicado: (2017)

Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation
por: Lim, Hyun-Joung, et al.
Publicado: (2019)

Clicked Cinnamic/Caffeic Esters and Amides as Radical Scavengers and 5-Lipoxygenase Inhibitors
por: Doiron, Jérémie A., et al.
Publicado: (2014)

A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by Betacoronavirus
por: Pereira, Rafaela das Dores, et al.
Publicado: (2023)

Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-κB Pathway
por: Su, Hui-Yuan, et al.
Publicado: (2022)

The Effects of Zileuton and Montelukast in Reperfusion-Induced Arrhythmias in Anesthetized Rats()
por: Gonca, Ersöz
Publicado: (2013)

Maximum Time of the Effect of Antileukotriene - Zileuton in Treatment of Patients with Bronchial Asthma
por: Morina, Naim, et al.
Publicado: (2016)

Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach
por: Kubick, Norwin, et al.
Publicado: (2020)

Clinical Study of Aspirin and Zileuton on Biomarkers of Tobacco-Related Carcinogenesis in Current Smokers
por: Garland, Linda L., et al.
Publicado: (2022)

The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study
por: Chen, Delphine L., et al.
Publicado: (2018)

Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway
por: Khophai, Sasikamon, et al.
Publicado: (2018)

Hydroxycinnamic Acid Antioxidants: An Electrochemical Overview
por: Teixeira, José, et al.
Publicado: (2013)

Development and Validation of a Liquid Chromatography-Mass Spectrometry Method for the Determination of Zileuton in Human Plasma
por: Prakash, Katakam, et al.
Publicado: (2014)

Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analogues
por: LeBlanc, Luc M., et al.
Publicado: (2012)

Oral Pharmacokinetics of Hydroxycinnamic Acids: An Updated Review
por: Veras, Kleyton Santos, et al.
Publicado: (2022)

Synthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents
por: Li, Jiyu, et al.
Publicado: (2017)

Synthesis of Steryl Hydroxycinnamates to Enhance Antioxidant Activity of Rapeseed Oil and Emulsions
por: Rabiej-Kozioł, Dobrochna, et al.
Publicado: (2020)

Zileuton Alleviates Radiation-Induced Cutaneous Ulcers via Inhibition of Senescence-Associated Secretory Phenotype in Rodents
por: Park, Mineon, et al.
Publicado: (2022)

Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions
por: Kumar, Ramakrishnan B., et al.
Publicado: (2020)

Zileuton Improves Memory Deficits, Amyloid and Tau Pathology in a Mouse Model of Alzheimer’s Disease with Plaques and Tangles
por: Chu, Jin, et al.
Publicado: (2013)

Comparison of oral montelukast with oral zileuton in acute asthma: A randomized, double-blind, placebo-controlled study
por: Magazine, Rahul, et al.
Publicado: (2016)

The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma
por: Dahlin, Amber, et al.
Publicado: (2018)

Production of Cinnamic and p-Hydroxycinnamic Acids in Engineered Microbes
por: Vargas-Tah, Alejandra, et al.
Publicado: (2015)

Occurrence and Biosynthesis of Alkyl Hydroxycinnamates in Plant Lipid Barriers
por: Domergue, Frédéric, et al.
Publicado: (2017)

Laccase and Tyrosinase Biosensors Used in the Determination of Hydroxycinnamic Acids
por: Bounegru, Alexandra Virginia, et al.
Publicado: (2021)

The Role of Hydroxycinnamic Acid Amide Pathway in Plant Immunity
por: Liu, Saifei, et al.
Publicado: (2022)

Facile Amidation of Non-Protected Hydroxycinnamic Acids for the Synthesis of Natural Phenol Amides
por: van Zadelhoff, Annemiek, et al.
Publicado: (2022)

Catalyst-free decarboxylation of 4-hydroxycinnamic acids: efficient synthesis of 4-vinylphenols
por: Yang, Qian, et al.
Publicado: (2022)

Hydroxycinnamic Acids and Their Derivatives: Cosmeceutical Significance, Challenges and Future Perspectives, a Review
por: Taofiq, Oludemi, et al.
Publicado: (2017)

Stress-responsive hydroxycinnamate glycosyltransferase modulates phenylpropanoid metabolism in Populus
por: Babst, Benjamin A., et al.
Publicado: (2014)

Modification of plant cell walls with hydroxycinnamic acids by BAHD acyltransferases
por: Chandrakanth, Niharika Nonavinakere, et al.
Publicado: (2023)

Revised Aspects into the Molecular Bases of Hydroxycinnamic Acid Metabolism in Lactobacilli
por: López de Felipe, Félix
Publicado: (2023)

Bioinspired Syntheses of Dimeric Hydroxycinnamic Acids (Lignans) and Hybrids, Using Phenol Oxidative Coupling as Key Reaction, and Medicinal Significance Thereof †
por: Magoulas, George E., et al.
Publicado: (2014)

The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart
por: Allain, Eric P., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_0rfcoh4v7jrvb40e8cf8rtmlat