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Viral surface geometry shapes influenza and coronavirus spike evolution through antibody pressure
The evolution of circulating viruses is shaped by their need to evade antibody response, which mainly targets the glycoprotein (spike). However, not all antigenic sites are targeted equally by antibodies, leading to complex immunodominance patterns. We used 3D computational models to estimate antibo...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587782/ https://www.ncbi.nlm.nih.gov/pubmed/33106808 http://dx.doi.org/10.1101/2020.10.20.347641 |