Viral surface geometry shapes influenza and coronavirus spike evolution through antibody pressure

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The evolution of circulating viruses is shaped by their need to evade antibody response, which mainly targets the glycoprotein (spike). However, not all antigenic sites are targeted equally by antibodies, leading to complex immunodominance patterns. We used 3D computational models to estimate antibo...

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Detalles Bibliográficos
Autor principal: Amitai, Assaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587782/
https://www.ncbi.nlm.nih.gov/pubmed/33106808
http://dx.doi.org/10.1101/2020.10.20.347641
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