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Copper Transporters? Glutathione Reactivity of Products of Cu–Aβ Digestion by Neprilysin

[Image: see text] Aβ(4–42) is the major subspecies of Aβ peptides characterized by avid Cu(II) binding via the ATCUN/NTS motif. It is thought to be produced in vivo proteolytically by neprilysin, but in vitro experiments in the presence of Cu(II) ions indicated preferable formation of C-terminally t...

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Detalles Bibliográficos
Autores principales: Stefaniak, Ewelina, Płonka, Dawid, Szczerba, Paulina, Wezynfeld, Nina E., Bal, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588031/
https://www.ncbi.nlm.nih.gov/pubmed/32212682
http://dx.doi.org/10.1021/acs.inorgchem.0c00427