Effects of Integrase Inhibitor–Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV

The NOD-like receptor protein family pyrin domain containing 3 (NLRP3) inflammasome, activated in the setting of HIV, contributes to pro-atherogenic inflammation. Among antriretroviral therapy–naïve people with HIV (vs controls), levels of caspase-1—a key component of the NLRP3 inflammasome—were sig...

Descripción completa

Detalles Bibliográficos
Autores principales: Toribio, Mabel, Burdo, Tricia H, Fulda, Evelynne S, Cetlin, Madeline, Chu, Sarah M, Feldpausch, Meghan N, Robbins, Gregory K, Neilan, Tomas G, Melbourne, Kathleen, Grinspoon, Steven K, Zanni, Markella V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588107/
https://www.ncbi.nlm.nih.gov/pubmed/33134423
http://dx.doi.org/10.1093/ofid/ofaa459
_version_ 1783600313450627072
author Toribio, Mabel
Burdo, Tricia H
Fulda, Evelynne S
Cetlin, Madeline
Chu, Sarah M
Feldpausch, Meghan N
Robbins, Gregory K
Neilan, Tomas G
Melbourne, Kathleen
Grinspoon, Steven K
Zanni, Markella V
author_facet Toribio, Mabel
Burdo, Tricia H
Fulda, Evelynne S
Cetlin, Madeline
Chu, Sarah M
Feldpausch, Meghan N
Robbins, Gregory K
Neilan, Tomas G
Melbourne, Kathleen
Grinspoon, Steven K
Zanni, Markella V
author_sort Toribio, Mabel
collection PubMed
description The NOD-like receptor protein family pyrin domain containing 3 (NLRP3) inflammasome, activated in the setting of HIV, contributes to pro-atherogenic inflammation. Among antriretroviral therapy–naïve people with HIV (vs controls), levels of caspase-1—a key component of the NLRP3 inflammasome—were significantly increased. Six months of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate significantly decreased caspase-1 levels in association with CD4+/CD8+ ratio recovery. Trial registration. ClinicalTrials.gov NCT 01766726.
format Online
Article
Text
id pubmed-7588107
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-75881072020-10-30 Effects of Integrase Inhibitor–Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV Toribio, Mabel Burdo, Tricia H Fulda, Evelynne S Cetlin, Madeline Chu, Sarah M Feldpausch, Meghan N Robbins, Gregory K Neilan, Tomas G Melbourne, Kathleen Grinspoon, Steven K Zanni, Markella V Open Forum Infect Dis Brief Reports The NOD-like receptor protein family pyrin domain containing 3 (NLRP3) inflammasome, activated in the setting of HIV, contributes to pro-atherogenic inflammation. Among antriretroviral therapy–naïve people with HIV (vs controls), levels of caspase-1—a key component of the NLRP3 inflammasome—were significantly increased. Six months of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate significantly decreased caspase-1 levels in association with CD4+/CD8+ ratio recovery. Trial registration. ClinicalTrials.gov NCT 01766726. Oxford University Press 2020-09-29 /pmc/articles/PMC7588107/ /pubmed/33134423 http://dx.doi.org/10.1093/ofid/ofaa459 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Toribio, Mabel
Burdo, Tricia H
Fulda, Evelynne S
Cetlin, Madeline
Chu, Sarah M
Feldpausch, Meghan N
Robbins, Gregory K
Neilan, Tomas G
Melbourne, Kathleen
Grinspoon, Steven K
Zanni, Markella V
Effects of Integrase Inhibitor–Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV
title Effects of Integrase Inhibitor–Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV
title_full Effects of Integrase Inhibitor–Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV
title_fullStr Effects of Integrase Inhibitor–Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV
title_full_unstemmed Effects of Integrase Inhibitor–Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV
title_short Effects of Integrase Inhibitor–Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV
title_sort effects of integrase inhibitor–based art on the nlrp3 inflammasome among art-naïve people with hiv
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588107/
https://www.ncbi.nlm.nih.gov/pubmed/33134423
http://dx.doi.org/10.1093/ofid/ofaa459
work_keys_str_mv AT toribiomabel effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv
AT burdotriciah effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv
AT fuldaevelynnes effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv
AT cetlinmadeline effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv
AT chusarahm effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv
AT feldpauschmeghann effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv
AT robbinsgregoryk effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv
AT neilantomasg effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv
AT melbournekathleen effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv
AT grinspoonstevenk effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv
AT zannimarkellav effectsofintegraseinhibitorbasedartonthenlrp3inflammasomeamongartnaivepeoplewithhiv

Ejemplares similares