High-throughput synthetic rescue for exhaustive characterization of suppressor mutations in human genes

Inherited or acquired mutations can lead to pathological outcomes. However, in a process defined as synthetic rescue, phenotypic outcome created by primary mutation is alleviated by suppressor mutations. An exhaustive characterization of these mutations in humans is extremely valuable to better comp...

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Detalles Bibliográficos
Autores principales: Kobaisi, Farah, Fayyad, Nour, Sulpice, Eric, Badran, Bassam, Fayyad-Kazan, Hussein, Rachidi, Walid, Gidrol, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588364/
https://www.ncbi.nlm.nih.gov/pubmed/32270227
http://dx.doi.org/10.1007/s00018-020-03519-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588364/
https://www.ncbi.nlm.nih.gov/pubmed/32270227
http://dx.doi.org/10.1007/s00018-020-03519-6

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