Structure/activity virtual screening and in vitro testing of small molecule inhibitors of 8-hydroxy-5-deazaflavin:NADPH oxidoreductase from gut methanogenic bacteria

Virtual screening techniques and in vitro binding/inhibitory assays were used to search within a set of more than 8,000 naturally occurring small ligands for candidate inhibitors of 8-hydroxy-5-deazaflavin:NADPH oxidoreductase (FNO) from Methanobrevibacter smithii, the enzyme that catalyses the bidi...

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Detalles Bibliográficos
Autores principales: Cuccioloni, Massimiliano, Bonfili, Laura, Cecarini, Valentina, Cocchioni, Filippo, Petrelli, Dezemona, Crotti, Elena, Zanchi, Raffaella, Eleuteri, Anna Maria, Angeletti, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588429/
https://www.ncbi.nlm.nih.gov/pubmed/32753591
http://dx.doi.org/10.1038/s41598-020-70042-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588429/
https://www.ncbi.nlm.nih.gov/pubmed/32753591
http://dx.doi.org/10.1038/s41598-020-70042-w

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