Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase

Human aspartate/asparagine-β-hydroxylase (AspH) is a 2-oxoglutarate (2OG) dependent oxygenase that catalyses the hydroxylation of Asp/Asn-residues of epidermal growth factor-like domains (EGFDs). AspH is reported to be upregulated on the cell surface of invasive cancer cells in a manner distinguishi...

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Detalles Bibliográficos
Autores principales: Brewitz, Lennart, Tumber, Anthony, Zhang, Xiaojin, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588595/
https://www.ncbi.nlm.nih.gov/pubmed/33069066
http://dx.doi.org/10.1016/j.bmc.2020.115675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588595/
https://www.ncbi.nlm.nih.gov/pubmed/33069066
http://dx.doi.org/10.1016/j.bmc.2020.115675

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