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Alerting the immune system to DNA damage: micronuclei as mediators

Healthy cells experience thousands of DNA lesions per day during normal cellular metabolism, and ionizing radiation and chemotherapeutic drugs rely on DNA damage to kill cancer cells. In response to such lesions, the DNA damage response (DDR) activates cell-cycle checkpoints, initiates DNA repair me...

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Detalles Bibliográficos
Autores principales: MacDonald, Kate M., Benguerfi, Soraya, Harding, Shane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588664/
https://www.ncbi.nlm.nih.gov/pubmed/32844183
http://dx.doi.org/10.1042/EBC20200016