Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining

Non-homologous end joining (NHEJ) is one of the two principal damage repair pathways for DNA double-strand breaks in cells. In this review, we give a brief overview of the system including a discussion of the effects of deregulation of NHEJ components in carcinogenesis and resistance to cancer thera...

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Detalles Bibliográficos
Autores principales: Kefala Stavridi, Antonia, Appleby, Robert, Liang, Shikang, Blundell, Tom L., Chaplin, Amanda K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588668/
https://www.ncbi.nlm.nih.gov/pubmed/32579168
http://dx.doi.org/10.1042/EBC20190092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588668/
https://www.ncbi.nlm.nih.gov/pubmed/32579168
http://dx.doi.org/10.1042/EBC20190092

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