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Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining

Non-homologous end joining (NHEJ) is one of the two principal damage repair pathways for DNA double-strand breaks in cells. In this review, we give a brief overview of the system including a discussion of the effects of deregulation of NHEJ components in carcinogenesis and resistance to cancer thera...

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Detalles Bibliográficos
Autores principales:	Kefala Stavridi, Antonia, Appleby, Robert, Liang, Shikang, Blundell, Tom L., Chaplin, Amanda K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Cancer
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588668/ https://www.ncbi.nlm.nih.gov/pubmed/32579168 http://dx.doi.org/10.1042/EBC20190092

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