Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern
BACKGROUND: Factors determining bisphosphonate compliance are not fully understood. We examined fluctuations in oral bisphosphonate dosing intervals to gauge therapeutic compliance in patients with osteoporosis. MATERIALS AND METHODS: Hospital data accruing between 2010 and 2017 were accessed to ret...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588837/ https://www.ncbi.nlm.nih.gov/pubmed/33122894 http://dx.doi.org/10.2147/PPA.S266697 |
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author | Ko, Kyung Rae Lee, Sangcheol Oh, Seo Yoon Kim, Ki-duk Park, Sin Hyung Lee, Soonchul |
author_facet | Ko, Kyung Rae Lee, Sangcheol Oh, Seo Yoon Kim, Ki-duk Park, Sin Hyung Lee, Soonchul |
author_sort | Ko, Kyung Rae |
collection | PubMed |
description | BACKGROUND: Factors determining bisphosphonate compliance are not fully understood. We examined fluctuations in oral bisphosphonate dosing intervals to gauge therapeutic compliance in patients with osteoporosis. MATERIALS AND METHODS: Hospital data accruing between 2010 and 2017 were accessed to retrospectively study patients ≥50 years old (N=1873), each prescribed bisphosphonate at initial diagnosis of osteoporosis. The medication possession ratio (MPR), calculated as total days supplied divided by length of follow-up, served to measure therapeutic compliance. We compared MPRs of various prescription patterns (daily, weekly, monthly, and switch [ie, ≥1 change in pattern] groups). We also analyzed the impact of age, sex, fracture history, surgical history, and comorbidities. Multiple regression analysis was ultimately performed, using MPR as a dependent variable. RESULTS: In our cohort (mean follow-up=5.7±2.4 years), once weekly dosing was the most common prescription pattern (1223/1873, 65.3%), as opposed to monthly (366/1873, 19.5%) or daily (164/1873, 8.8%) dosing. A total of 120 patients (6.4%) comprising the switch group changed dosing patterns during the study period. MPR was significantly higher in the switch group (32.8±22.7) than in the other three groups (daily, 21.9±25.9; weekly, 22.7±27.3; monthly, 23.2±27.7). In multiple regression analysis, younger age (P<0.001), female sex (P=0.004), and switching of prescription pattern (decrease or increase frequency) were factors significantly associated with higher MPR, signaling better compliance. CONCLUSION: Better bisphosphonate compliance was associated with physician-modified dosing patterns. We therefore recommend adjustments of prescription intervals in poorly compliant patients requiring long-term treatment. |
format | Online Article Text |
id | pubmed-7588837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-75888372020-10-28 Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern Ko, Kyung Rae Lee, Sangcheol Oh, Seo Yoon Kim, Ki-duk Park, Sin Hyung Lee, Soonchul Patient Prefer Adherence Original Research BACKGROUND: Factors determining bisphosphonate compliance are not fully understood. We examined fluctuations in oral bisphosphonate dosing intervals to gauge therapeutic compliance in patients with osteoporosis. MATERIALS AND METHODS: Hospital data accruing between 2010 and 2017 were accessed to retrospectively study patients ≥50 years old (N=1873), each prescribed bisphosphonate at initial diagnosis of osteoporosis. The medication possession ratio (MPR), calculated as total days supplied divided by length of follow-up, served to measure therapeutic compliance. We compared MPRs of various prescription patterns (daily, weekly, monthly, and switch [ie, ≥1 change in pattern] groups). We also analyzed the impact of age, sex, fracture history, surgical history, and comorbidities. Multiple regression analysis was ultimately performed, using MPR as a dependent variable. RESULTS: In our cohort (mean follow-up=5.7±2.4 years), once weekly dosing was the most common prescription pattern (1223/1873, 65.3%), as opposed to monthly (366/1873, 19.5%) or daily (164/1873, 8.8%) dosing. A total of 120 patients (6.4%) comprising the switch group changed dosing patterns during the study period. MPR was significantly higher in the switch group (32.8±22.7) than in the other three groups (daily, 21.9±25.9; weekly, 22.7±27.3; monthly, 23.2±27.7). In multiple regression analysis, younger age (P<0.001), female sex (P=0.004), and switching of prescription pattern (decrease or increase frequency) were factors significantly associated with higher MPR, signaling better compliance. CONCLUSION: Better bisphosphonate compliance was associated with physician-modified dosing patterns. We therefore recommend adjustments of prescription intervals in poorly compliant patients requiring long-term treatment. Dove 2020-10-22 /pmc/articles/PMC7588837/ /pubmed/33122894 http://dx.doi.org/10.2147/PPA.S266697 Text en © 2020 Ko et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Ko, Kyung Rae Lee, Sangcheol Oh, Seo Yoon Kim, Ki-duk Park, Sin Hyung Lee, Soonchul Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern |
title | Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern |
title_full | Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern |
title_fullStr | Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern |
title_full_unstemmed | Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern |
title_short | Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern |
title_sort | long-term oral bisphosphonate compliance focusing on switching of prescription pattern |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588837/ https://www.ncbi.nlm.nih.gov/pubmed/33122894 http://dx.doi.org/10.2147/PPA.S266697 |
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