Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern

BACKGROUND: Factors determining bisphosphonate compliance are not fully understood. We examined fluctuations in oral bisphosphonate dosing intervals to gauge therapeutic compliance in patients with osteoporosis. MATERIALS AND METHODS: Hospital data accruing between 2010 and 2017 were accessed to ret...

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Autores principales: Ko, Kyung Rae, Lee, Sangcheol, Oh, Seo Yoon, Kim, Ki-duk, Park, Sin Hyung, Lee, Soonchul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588837/
https://www.ncbi.nlm.nih.gov/pubmed/33122894
http://dx.doi.org/10.2147/PPA.S266697
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author Ko, Kyung Rae
Lee, Sangcheol
Oh, Seo Yoon
Kim, Ki-duk
Park, Sin Hyung
Lee, Soonchul
author_facet Ko, Kyung Rae
Lee, Sangcheol
Oh, Seo Yoon
Kim, Ki-duk
Park, Sin Hyung
Lee, Soonchul
author_sort Ko, Kyung Rae
collection PubMed
description BACKGROUND: Factors determining bisphosphonate compliance are not fully understood. We examined fluctuations in oral bisphosphonate dosing intervals to gauge therapeutic compliance in patients with osteoporosis. MATERIALS AND METHODS: Hospital data accruing between 2010 and 2017 were accessed to retrospectively study patients ≥50 years old (N=1873), each prescribed bisphosphonate at initial diagnosis of osteoporosis. The medication possession ratio (MPR), calculated as total days supplied divided by length of follow-up, served to measure therapeutic compliance. We compared MPRs of various prescription patterns (daily, weekly, monthly, and switch [ie, ≥1 change in pattern] groups). We also analyzed the impact of age, sex, fracture history, surgical history, and comorbidities. Multiple regression analysis was ultimately performed, using MPR as a dependent variable. RESULTS: In our cohort (mean follow-up=5.7±2.4 years), once weekly dosing was the most common prescription pattern (1223/1873, 65.3%), as opposed to monthly (366/1873, 19.5%) or daily (164/1873, 8.8%) dosing. A total of 120 patients (6.4%) comprising the switch group changed dosing patterns during the study period. MPR was significantly higher in the switch group (32.8±22.7) than in the other three groups (daily, 21.9±25.9; weekly, 22.7±27.3; monthly, 23.2±27.7). In multiple regression analysis, younger age (P<0.001), female sex (P=0.004), and switching of prescription pattern (decrease or increase frequency) were factors significantly associated with higher MPR, signaling better compliance. CONCLUSION: Better bisphosphonate compliance was associated with physician-modified dosing patterns. We therefore recommend adjustments of prescription intervals in poorly compliant patients requiring long-term treatment.
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spelling pubmed-75888372020-10-28 Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern Ko, Kyung Rae Lee, Sangcheol Oh, Seo Yoon Kim, Ki-duk Park, Sin Hyung Lee, Soonchul Patient Prefer Adherence Original Research BACKGROUND: Factors determining bisphosphonate compliance are not fully understood. We examined fluctuations in oral bisphosphonate dosing intervals to gauge therapeutic compliance in patients with osteoporosis. MATERIALS AND METHODS: Hospital data accruing between 2010 and 2017 were accessed to retrospectively study patients ≥50 years old (N=1873), each prescribed bisphosphonate at initial diagnosis of osteoporosis. The medication possession ratio (MPR), calculated as total days supplied divided by length of follow-up, served to measure therapeutic compliance. We compared MPRs of various prescription patterns (daily, weekly, monthly, and switch [ie, ≥1 change in pattern] groups). We also analyzed the impact of age, sex, fracture history, surgical history, and comorbidities. Multiple regression analysis was ultimately performed, using MPR as a dependent variable. RESULTS: In our cohort (mean follow-up=5.7±2.4 years), once weekly dosing was the most common prescription pattern (1223/1873, 65.3%), as opposed to monthly (366/1873, 19.5%) or daily (164/1873, 8.8%) dosing. A total of 120 patients (6.4%) comprising the switch group changed dosing patterns during the study period. MPR was significantly higher in the switch group (32.8±22.7) than in the other three groups (daily, 21.9±25.9; weekly, 22.7±27.3; monthly, 23.2±27.7). In multiple regression analysis, younger age (P<0.001), female sex (P=0.004), and switching of prescription pattern (decrease or increase frequency) were factors significantly associated with higher MPR, signaling better compliance. CONCLUSION: Better bisphosphonate compliance was associated with physician-modified dosing patterns. We therefore recommend adjustments of prescription intervals in poorly compliant patients requiring long-term treatment. Dove 2020-10-22 /pmc/articles/PMC7588837/ /pubmed/33122894 http://dx.doi.org/10.2147/PPA.S266697 Text en © 2020 Ko et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ko, Kyung Rae
Lee, Sangcheol
Oh, Seo Yoon
Kim, Ki-duk
Park, Sin Hyung
Lee, Soonchul
Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern
title Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern
title_full Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern
title_fullStr Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern
title_full_unstemmed Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern
title_short Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern
title_sort long-term oral bisphosphonate compliance focusing on switching of prescription pattern
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588837/
https://www.ncbi.nlm.nih.gov/pubmed/33122894
http://dx.doi.org/10.2147/PPA.S266697
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