Metabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity

INTRODUCTION: Berberrubine (BRB), an isoquinoline alkaloid, is a major constituent of medicinal plants Coptis chinensis Franch or Phellodendron chinense Schneid. BRB exhibits various pharmacological activities, whereas exposure to BRB may cause toxicity in experimental animals. METHODS: In this stud...

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Detalles Bibliográficos
Autores principales: Wang, Kai, Rao, Jinqiu, Zhang, Tingting, Gao, Qing, Zhang, Jichao, Guang, Chenxi, Ding, Liqin, Qiu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588839/
https://www.ncbi.nlm.nih.gov/pubmed/33122887
http://dx.doi.org/10.2147/DDDT.S274627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588839/
https://www.ncbi.nlm.nih.gov/pubmed/33122887
http://dx.doi.org/10.2147/DDDT.S274627

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