In Vivo, In Vitro and In Silico Studies of the Hybrid Compound AA3266, an Opioid Agonist/NK1R Antagonist with Selective Cytotoxicity

AA3266 is a hybrid compound consisting of opioid receptor agonist and neurokinin-1 receptor (NK1R) antagonist pharmacophores. It was designed with the desire to have an analgesic molecule with improved properties and auxiliary anticancer activity. Previously, the compound was found to exhibit high a...

Descripción completa

Detalles Bibliográficos
Autores principales: Matalińska, Joanna, Lipiński, Piotr F. J., Kosson, Piotr, Kosińska, Katarzyna, Misicka, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588979/
https://www.ncbi.nlm.nih.gov/pubmed/33086743
http://dx.doi.org/10.3390/ijms21207738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588979/
https://www.ncbi.nlm.nih.gov/pubmed/33086743
http://dx.doi.org/10.3390/ijms21207738

Ejemplares similares