12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-δ/PKD/ERK Signaling Pathway

Prostratin, a non-tumor promoting 12-deoxyphorbol ester, has been reported as a protein kinase C (PKC) activator and is shown to have anti-proliferative activity in certain cancer cell types. Here we show that GRC-2, a prostratin analogue isolated from Euphorbia grandicornis, is ten-fold more potent...

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Detalles Bibliográficos
Autores principales: Tsai, Ju-Ying, Rédei, Dóra, Hohmann, Judit, Wu, Chin-Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589005/
https://www.ncbi.nlm.nih.gov/pubmed/33066446
http://dx.doi.org/10.3390/ijms21207579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589005/
https://www.ncbi.nlm.nih.gov/pubmed/33066446
http://dx.doi.org/10.3390/ijms21207579

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