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12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-δ/PKD/ERK Signaling Pathway

Prostratin, a non-tumor promoting 12-deoxyphorbol ester, has been reported as a protein kinase C (PKC) activator and is shown to have anti-proliferative activity in certain cancer cell types. Here we show that GRC-2, a prostratin analogue isolated from Euphorbia grandicornis, is ten-fold more potent...

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Detalles Bibliográficos
Autores principales:	Tsai, Ju-Ying, Rédei, Dóra, Hohmann, Judit, Wu, Chin-Chung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589005/ https://www.ncbi.nlm.nih.gov/pubmed/33066446 http://dx.doi.org/10.3390/ijms21207579

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