Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives

We report herein the design, synthesis, biological evaluation, and molecular modelling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca(+2) channels also showing antioxidant and neuroprotective activities. The new MTDL, dialkyl 2,6-dimethyl-4-(4-((...

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Detalles Bibliográficos
Autores principales: Pachón Angona, Irene, Martin, Helene, Daniel, Solene, Moraleda, Ignacio, Bonet, Alexandre, Wnorowski, Artur, Maj, Maciej, Jozwiak, Krzysztof, Iriepa, Isabel, Refouvelet, Bernard, Marco-Contelles, José, Ismaili, Lhassane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589057/
https://www.ncbi.nlm.nih.gov/pubmed/33081112
http://dx.doi.org/10.3390/ijms21207652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589057/
https://www.ncbi.nlm.nih.gov/pubmed/33081112
http://dx.doi.org/10.3390/ijms21207652

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