Using a Human Papillomavirus Model to Study DNA Replication and Repair of Wild Type and Damaged DNA Templates in Mammalian Cells

Human papillomaviruses have 8kbp DNA episomal genomes that replicate autonomously from host DNA. During initial infection, the virus increases its copy number to 20–50 copies per cell, causing torsional stress on the replicating DNA. This activates the DNA damage response (DDR) and HPV replicates it...

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Detalles Bibliográficos
Autores principales: Das, Dipon, Bristol, Molly L., Pichierri, Pietro, Morgan, Iain M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589113/
https://www.ncbi.nlm.nih.gov/pubmed/33066318
http://dx.doi.org/10.3390/ijms21207564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589113/
https://www.ncbi.nlm.nih.gov/pubmed/33066318
http://dx.doi.org/10.3390/ijms21207564

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