Identification of Putative Non-Substrate-Based XT-I Inhibitors by Natural Product Library Screening

Fibroproliferative diseases are characterized by excessive accumulation of extracellular matrix (ECM) components leading to organ dysfunction. This process is characterized by an increase in myofibroblast content and enzyme activity of xylosyltransferase-I (XT-I), the initial enzyme in proteoglycan...

Descripción completa

Detalles Bibliográficos
Autores principales: Ly, Thanh-Diep, Kleine, Anika, Fischer, Bastian, Schmidt, Vanessa, Hendig, Doris, Kuhn, Joachim, Knabbe, Cornelius, Faust, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589200/
https://www.ncbi.nlm.nih.gov/pubmed/33096778
http://dx.doi.org/10.3390/biom10101467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589200/
https://www.ncbi.nlm.nih.gov/pubmed/33096778
http://dx.doi.org/10.3390/biom10101467

Ejemplares similares