Spiropyran Meets Guanine Quadruplexes: Isomerization Mechanism and DNA Binding Modes of Quinolizidine‐Substituted Spiropyran Probes

The recent delivery of a fluorescent quinolizidine‐substituted spiropyran, which is able to switch in vivo and bind to guanine quadruplexes (G4) at physiological pH values, urged us to elucidate its molecular switching and binding mechanism. Combining multiscale dynamical studies and accurate quantu...

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Detalles Bibliográficos
Autores principales: Avagliano, Davide, Sánchez‐Murcia, Pedro A., González, Leticia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589282/
https://www.ncbi.nlm.nih.gov/pubmed/32368812
http://dx.doi.org/10.1002/chem.202001586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589282/
https://www.ncbi.nlm.nih.gov/pubmed/32368812
http://dx.doi.org/10.1002/chem.202001586

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