Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells

Iron is crucial to satisfy several mitochondrial functions including energy metabolism and oxidative phosphorylation. Patients affected by Myelodysplastic Syndromes (MDS) and acute myeloid leukemia (AML) are frequently characterized by iron overload (IOL), due to continuous red blood cell (RBC) tran...

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Detalles Bibliográficos
Autores principales: Calabrese, Chiara, Panuzzo, Cristina, Stanga, Serena, Andreani, Giacomo, Ravera, Silvia, Maglione, Alessandro, Pironi, Lucrezia, Petiti, Jessica, Shahzad Ali, Muhammad, Scaravaglio, Patrizia, Napoli, Francesca, Fava, Carmen, De Gobbi, Marco, Frassoni, Francesco, Saglio, Giuseppe, Bracco, Enrico, Pergolizzi, Barbara, Cilloni, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589297/
https://www.ncbi.nlm.nih.gov/pubmed/33081324
http://dx.doi.org/10.3390/ijms21207674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589297/
https://www.ncbi.nlm.nih.gov/pubmed/33081324
http://dx.doi.org/10.3390/ijms21207674

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