Optical Control of GABA(A) Receptors with a Fulgimide‐Based Potentiator

Optogenetic and photopharmacological tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a pure potentiator of ionotropic γ‐aminobutyric aci...

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Detalles Bibliográficos
Autores principales: Rustler, Karin, Maleeva, Galyna, Gomila, Alexandre M. J., Gorostiza, Pau, Bregestovski, Piotr, König, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589408/
https://www.ncbi.nlm.nih.gov/pubmed/32307732
http://dx.doi.org/10.1002/chem.202000710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589408/
https://www.ncbi.nlm.nih.gov/pubmed/32307732
http://dx.doi.org/10.1002/chem.202000710

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