Tafazzin Mutation Affecting Cardiolipin Leads to Increased Mitochondrial Superoxide Anions and Mitophagy Inhibition in Barth Syndrome

Tafazzin is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation. Mutations of the tafazzin gene cause Barth syndrome, which is characterized by mitochondrial dysfunction and dilated cardiomyopathy, leading to p...

Descripción completa

Detalles Bibliográficos
Autores principales: Petit, Patrice X., Ardilla-Osorio, Hector, Penalvia, Lucile, Nathan E., Rainey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589545/
https://www.ncbi.nlm.nih.gov/pubmed/33096711
http://dx.doi.org/10.3390/cells9102333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589545/
https://www.ncbi.nlm.nih.gov/pubmed/33096711
http://dx.doi.org/10.3390/cells9102333

Ejemplares similares