Sodium-Glucose Co-Transporter 2 Inhibitors Correct Metabolic Maladaptation of Proximal Tubular Epithelial Cells in High-Glucose Conditions

Glucose filtered in the glomerulus is actively reabsorbed by sodium-glucose co-transporter 2 (SGLT2) in proximal tubular epithelial cells (PTEC) and passively returned to the blood via glucose transporter 2 (GLUT2). Healthy PTEC rely primarily on fatty acid beta-oxidation (FAO) for energy. In phase...

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Detalles Bibliográficos
Autores principales: Shirakawa, Kohsuke, Sano, Motoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589591/
https://www.ncbi.nlm.nih.gov/pubmed/33081406
http://dx.doi.org/10.3390/ijms21207676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589591/
https://www.ncbi.nlm.nih.gov/pubmed/33081406
http://dx.doi.org/10.3390/ijms21207676

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