The Ionophores CCCP and Gramicidin but Not Nigericin Inhibit Trypanosoma brucei Aquaglyceroporins at Neutral pH

Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei parasites. The T. brucei aquaglyceroporin isoform 2, TbAQP2, has been linked to the uptake of pentamidine. Negative membrane potentials and transmembrane pH gradients were suggested to promote transport of the dicationic antitrypano...

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Detalles Bibliográficos
Autores principales: Petersen, Lea Madlen, Beitz, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589649/
https://www.ncbi.nlm.nih.gov/pubmed/33096791
http://dx.doi.org/10.3390/cells9102335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589649/
https://www.ncbi.nlm.nih.gov/pubmed/33096791
http://dx.doi.org/10.3390/cells9102335

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