Chronic Valproic Acid Administration Increases Plasma, Liver, and Brain Ammonia Concentration and Suppresses Glutamine Synthetase Activity

Asymptomatic valproic acid (VPA)-induced hyperammonemia in the absence of liver impairment is fairly common. However, the underlying mechanisms through which VPA causes elevation in plasma ammonia (NH(4)) remains under investigation. Male Sprague Dawley rats (n = 72) were randomly allocated to recei...

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Detalles Bibliográficos
Autores principales: Badawy, Abdelnaser A., Elghaba, Rasha, Soliman, Mohamed, Hussein, Abdelaziz M., AlSadrah, Sana A., Awadalla, Amira, Abulseoud, Osama A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589689/
https://www.ncbi.nlm.nih.gov/pubmed/33096612
http://dx.doi.org/10.3390/brainsci10100759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589689/
https://www.ncbi.nlm.nih.gov/pubmed/33096612
http://dx.doi.org/10.3390/brainsci10100759

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