Mechanism of Albuminuria Reduction by Chymase Inhibition in Diabetic Mice

Chymase has several functions, such as angiotensin II formation, which can promote diabetic kidney disease (DKD). In this study, we evaluated the effect of the chymase inhibitor TY-51469 on DKD in diabetic db/db mice. Diabetic mice were administered TY-51469 (10 mg/kg/day) or placebo for 4 weeks. No...

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Detalles Bibliográficos
Autores principales: Terai, Kentaro, Jin, Denan, Watase, Kenji, Imagawa, Akihisa, Takai, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589797/
https://www.ncbi.nlm.nih.gov/pubmed/33050674
http://dx.doi.org/10.3390/ijms21207495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589797/
https://www.ncbi.nlm.nih.gov/pubmed/33050674
http://dx.doi.org/10.3390/ijms21207495

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