Computational SNP Analysis and Molecular Simulation Revealed the Most Deleterious Missense Variants in the NBD1 Domain of Human ABCA1 Transporter

The ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound exporter protein involved in regulating serum HDL level by exporting cholesterol and phospholipids to load up in lipid-poor ApoA-I and ApoE, which allows the formation of nascent HDL. Mutations in the ABCA1 gene, when presents in bo...

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Detalles Bibliográficos
Autores principales: Dash, Raju, Ali, Md. Chayan, Rana, Md. Liton, Munni, Yeasmin Akter, Barua, Largess, Jahan, Israt, Haque, Mst. Fatema, Hannan, Md. Abdul, Moon, Il Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589834/
https://www.ncbi.nlm.nih.gov/pubmed/33066695
http://dx.doi.org/10.3390/ijms21207606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589834/
https://www.ncbi.nlm.nih.gov/pubmed/33066695
http://dx.doi.org/10.3390/ijms21207606

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