Cargando…

Computational SNP Analysis and Molecular Simulation Revealed the Most Deleterious Missense Variants in the NBD1 Domain of Human ABCA1 Transporter

The ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound exporter protein involved in regulating serum HDL level by exporting cholesterol and phospholipids to load up in lipid-poor ApoA-I and ApoE, which allows the formation of nascent HDL. Mutations in the ABCA1 gene, when presents in bo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dash, Raju, Ali, Md. Chayan, Rana, Md. Liton, Munni, Yeasmin Akter, Barua, Largess, Jahan, Israt, Haque, Mst. Fatema, Hannan, Md. Abdul, Moon, Il Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589834/ https://www.ncbi.nlm.nih.gov/pubmed/33066695 http://dx.doi.org/10.3390/ijms21207606

Ejemplares similares

Computational Insights into the Deleterious Impacts of Missense Variants on N-Acetyl-d-glucosamine Kinase Structure and Function
por: Dash, Raju, et al.
Publicado: (2021)

Gut Microbiota in Autophagy Regulation: New Therapeutic Perspective in Neurodegeneration
por: Mitra, Sarmistha, et al.
Publicado: (2023)

Targeting Estrogen Signaling in the Radiation-induced Neurodegeneration: A Possible Role of Phytoestrogens
por: Mitra, Sarmistha, et al.
Publicado: (2023)

Structural Consequence of Non-Synonymous Single-Nucleotide Variants in the N-Terminal Domain of LIS1
por: Choi, Ho Jin, et al.
Publicado: (2022)

Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding
por: Dash, Raju, et al.
Publicado: (2019)

Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration
por: Mitra, Sarmistha, et al.
Publicado: (2022)

Differential Effects of the Processed and Unprocessed Garlic (Allium sativum L.) Ethanol Extracts on Neuritogenesis and Synaptogenesis in Rat Primary Hippocampal Neurons
por: Munni, Yeasmin Akter, et al.
Publicado: (2023)

Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function
por: Dash, Raju, et al.
Publicado: (2022)

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety
por: Hannan, Md. Abdul, et al.
Publicado: (2021)

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential
por: Akter, Sahida, et al.
Publicado: (2021)

Identification of deleterious single nucleotide polymorphism (SNP)s in the human TBX5 gene & prediction of their structural & functional consequences: An in silico approach
por: Mahfuz, A.M.U.B., et al.
Publicado: (2021)

The NBD-NBD interface is not the sole determinant for transport in ABC transporters
por: Dönmez, Yaprak, et al.
Publicado: (2012)

Bioaccumulation and Bioremediation of Heavy Metals in Fishes—A Review
por: Jamil Emon, Farhan, et al.
Publicado: (2023)

Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis
por: Kapoor, Parth, et al.
Publicado: (2020)

Increasing trend of antibiotic resistance in Shigella in Bangladesh: a plasmid-mediated transfer of mphA macrolide resistance gene
por: Asad, Asaduzzaman, et al.
Publicado: (2023)

Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene
por: Bappy, Md. Nazmul Islam, et al.
Publicado: (2022)

Protective roles of vitamin C and 5-aminosalicylic acid on reproduction in acrylamide intoxicated male mice
por: Eftakhar Jahan Bhuiyan, Md., et al.
Publicado: (2023)

Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer’s disease
por: De Roeck, Arne, et al.
Publicado: (2017)

Medial collateral ligament calcification: a rare knee pain entity with literature review
por: Siddiq, Md Abu Bakar, et al.
Publicado: (2017)

The rapid spreading of monkeypox virus is a threat for global public health: What should we do to fight this old enemy?
por: Akter, Mst. Sarmin, et al.
Publicado: (2022)

Expedition of monkeypox virus from Africa to rest of the world: What has made this old foe so powerful?
por: Sohan, Md, et al.
Publicado: (2022)

Keratinolytic protease from Pseudomonas aeruginosa for leather skin processing
por: Moonnee, Yeasmin Akter, et al.
Publicado: (2021)

Functional Characterization of ABCA4 Missense Variants Linked to Stargardt Macular Degeneration
por: Garces, Fabian A., et al.
Publicado: (2020)

3β, 6β-dichloro-5-hydroxy-5α-cholestane facilitates neuronal development through modulating TrkA signaling regulated proteins in primary hippocampal neuron
por: Hannan, Md. Abdul, et al.
Publicado: (2019)

SDS, a structural disruption score for assessment of missense variant deleteriousness
por: Preeprem, Thanawadee, et al.
Publicado: (2014)

In silico analyses of deleterious missense SNPs of human apolipoprotein E3
por: Pires, Allan S., et al.
Publicado: (2017)

Impact of deleterious missense PRKCI variants on structural and functional dynamics of protein
por: Shah, Hania, et al.
Publicado: (2022)

Protocol for a randomized clinical trial comparing the efficacy of Structured Diet (SD) and Regular Therapy (RT) for adolescents with malnutrition having Autism Spectrum Disorder (ASD)
por: Akter, Ruksana, et al.
Publicado: (2023)

Draft genome sequence of Staphylococcus gallinarum BAU_KME002 strain isolated from egg surface in Bangladesh
por: Ballah, Fatimah Muhammad, et al.
Publicado: (2023)

Gelidium amansii Attenuates Hypoxia/Reoxygenation-Induced Oxidative Injury in Primary Hippocampal Neurons through Suppressing GluN2B Expression
por: Hannan, Md. Abdul, et al.
Publicado: (2020)

Wallet Neuritis – An Example of Peripheral Sensitization
por: Siddiq, Md Abu Bakar, et al.
Publicado: (2018)

Reproductive Health Rights of Women in the Rural Areas of Meherpur District in Bangladesh
por: Hossain, Md Kamal, et al.
Publicado: (2011)

Tunable Photoswitching in Norbornadiene (NBD)/Quadricyclane (QC) – Fullerene Hybrids
por: Lorenz, Patrick, et al.
Publicado: (2021)

Visualizing NBD-lipid Uptake in Mammalian Cells by Confocal Microscopy
por: Baum, Julia F., et al.
Publicado: (2023)

Musculoskeletal health complaints: A growing concern that should be investigated elaborately in Bangladesh
por: Ferdous, Jannatul, et al.
Publicado: (2022)

Stargardt disease-associated missense and synonymous ABCA4 variants result in aberrant splicing
por: Kaltak, Melita, et al.
Publicado: (2023)

LIST-S2: taxonomy based sorting of deleterious missense mutations across species
por: Malhis, Nawar, et al.
Publicado: (2020)

MISTIC: A prediction tool to reveal disease-relevant deleterious missense variants
por: Chennen, Kirsley, et al.
Publicado: (2020)

Computational Identification of Most Deleterious Missense Mutations in Human PD-1 Gene
por: Ahmed Al-Madhagi, Haitham
Publicado: (2023)

Homology modeling and assigned functional annotation of an uncharacterized antitoxin protein from Streptomyces xinghaiensis
por: Oany, Arafat Rahman, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_9rjas9850r7st3165bio9jpkrn