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Looking for Targets to Restore the Contractile Function in Congenital Myopathy Caused by Gln(147)Pro Tropomyosin

We have used the technique of polarized microfluorimetry to obtain new insight into the pathogenesis of skeletal muscle disease caused by the Gln(147)Pro substitution in β-tropomyosin (Tpm2.2). The spatial rearrangements of actin, myosin and tropomyosin in the single muscle fiber containing reconsti...

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Detalles Bibliográficos
Autores principales: Karpicheva, Olga E., Simonyan, Armen O., Rysev, Nikita A., Redwood, Charles S., Borovikov, Yurii S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589864/
https://www.ncbi.nlm.nih.gov/pubmed/33066566
http://dx.doi.org/10.3390/ijms21207590