Increased Carrier Peptide Stability through pH Adjustment Improves Insulin and PTH(1-34) Delivery In Vitro and In Vivo Rather than by Enforced Carrier Peptide-Cargo Complexation

Oral delivery of therapeutic peptides is hampered by their large molecular size and labile nature, thus limiting their permeation across the intestinal epithelium. Promising approaches to overcome the latter include co-administration with carrier peptides. In this study, the cell-penetrating peptide...

Descripción completa

Detalles Bibliográficos
Autores principales: Kristensen, Mie, Guldsmed Diedrichsen, Ragna, Vetri, Valeria, Foderà, Vito, Mørck Nielsen, Hanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589992/
https://www.ncbi.nlm.nih.gov/pubmed/33092079
http://dx.doi.org/10.3390/pharmaceutics12100993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589992/
https://www.ncbi.nlm.nih.gov/pubmed/33092079
http://dx.doi.org/10.3390/pharmaceutics12100993

Ejemplares similares