All-Atomic Molecular Dynamic Studies of Human and Drosophila CDK8: Insights into Their Kinase Domains, the LXXLL Motifs, and Drug Binding Site

Cyclin-dependent kinase 8 (CDK8) and its regulatory partner Cyclin C (CycC) play conserved roles in modulating RNA polymerase II (Pol II)-dependent gene expression. To understand the structure and function relations of CDK8, we analyzed the structures of human and Drosophila CDK8 proteins using mole...

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Detalles Bibliográficos
Autores principales: Xu, Wu, Xie, Xiao-Jun, Faust, Ali K., Liu, Mengmeng, Li, Xiao, Chen, Feng, Naquin, Ashlin A., Walton, Avery C., Kishbaugh, Peter W., Ji, Jun-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590003/
https://www.ncbi.nlm.nih.gov/pubmed/33053834
http://dx.doi.org/10.3390/ijms21207511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590003/
https://www.ncbi.nlm.nih.gov/pubmed/33053834
http://dx.doi.org/10.3390/ijms21207511

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