Cargando…

All-Atomic Molecular Dynamic Studies of Human and Drosophila CDK8: Insights into Their Kinase Domains, the LXXLL Motifs, and Drug Binding Site

Cyclin-dependent kinase 8 (CDK8) and its regulatory partner Cyclin C (CycC) play conserved roles in modulating RNA polymerase II (Pol II)-dependent gene expression. To understand the structure and function relations of CDK8, we analyzed the structures of human and Drosophila CDK8 proteins using mole...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Wu, Xie, Xiao-Jun, Faust, Ali K., Liu, Mengmeng, Li, Xiao, Chen, Feng, Naquin, Ashlin A., Walton, Avery C., Kishbaugh, Peter W., Ji, Jun-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590003/ https://www.ncbi.nlm.nih.gov/pubmed/33053834 http://dx.doi.org/10.3390/ijms21207511

Ejemplares similares

Characterization of Fusarium verticillioides Med1 LxxLL Motif Involved in Fumonisin Biosynthesis
por: Zhou, Zehua, et al.
Publicado: (2023)

Integrity of the LXXLL motif in Stat6 is required for the inhibition of breast cancer cell growth and enhancement of differentiation in the context of progesterone
por: Wei, Min, et al.
Publicado: (2014)

Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines
por: Davis, Melissa B, et al.
Publicado: (2011)

ERβ Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus
por: Webb, Paul, et al.
Publicado: (2003)

Human ADA3 regulates RARα transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket
por: Li, Chia-Wei, et al.
Publicado: (2010)

LXXLL Peptide Converts Transportan 10 to a Potent Inducer of Apoptosis in Breast Cancer Cells
por: Tints, Kairit, et al.
Publicado: (2014)

Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila
por: Li, Xiao, et al.
Publicado: (2022)

The interaction between androgen receptor and semenogelin I: a synthetic LxxLL peptide antagonist inhibits the growth of prostate cancer cells
por: Li, Peng, et al.
Publicado: (2018)

Motif-All: discovering all phosphorylation motifs
por: He, Zengyou, et al.
Publicado: (2011)

The Mediator CDK8-Cyclin C complex modulates Dpp signaling in Drosophila by stimulating Mad-dependent transcription
por: Li, Xiao, et al.
Publicado: (2020)

Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization
por: Örd, Mihkel, et al.
Publicado: (2020)

The CDK-activating kinase Cdk7: Taking yes for an answer
por: Schachter, Miriam Merzel, et al.
Publicado: (2013)

Regulatory functions of the Mediator kinases CDK8 and CDK19
por: Fant, Charli B., et al.
Publicado: (2018)

Unanticipated domain requirements for Drosophila Wnk kinase in vivo
por: Yarikipati, Prathibha, et al.
Publicado: (2023)

Drosophila Xpd Regulates Cdk7 Localization, Mitotic Kinase Activity, Spindle Dynamics, and Chromosome Segregation
por: Li, Xiaoming, et al.
Publicado: (2010)

Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
por: Dannappel, Marius Volker, et al.
Publicado: (2019)

The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis
por: Kandachar, Vasundhara, et al.
Publicado: (2008)

CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila
por: Xie, Xiao-Jun, et al.
Publicado: (2015)

The anti-atherogenic cytokine interleukin-33 inhibits the expression of a disintegrin and metalloproteinase with thrombospondin motifs-1, -4 and -5 in human macrophages: Requirement of extracellular signal-regulated kinase, c-Jun N-terminal kinase and phosphoinositide 3-kinase signaling pathways()
por: Ashlin, Tim G., et al.
Publicado: (2014)

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain
por: Estevam, Gabriella O., et al.
Publicado: (2023)

Learning motifs and their hierarchies in atomic resolution microscopy
por: Dan, Jiadong, et al.
Publicado: (2022)

JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21
por: Colleoni, B, et al.
Publicado: (2017)

Cdk5: An Emerging Kinase in Pain Signaling
por: Pareek, Tej Kumar, et al.
Publicado: (2012)

A Gly-Zipper Motif Mediates Homodimerization of the Transmembrane Domain of the Mitochondrial Kinase ADCK3
por: Khadria, Ambalika S., et al.
Publicado: (2014)

The conserved protein kinase-A target motif in synapsin of Drosophila is effectively modified by pre-mRNA editing
por: Diegelmann, Sören, et al.
Publicado: (2006)

Effects of the Cyclin-Dependent Kinase 10 (CDK10) on the Tamoxifen Sensitivity of Keloid Samples
por: Liu, Ying, et al.
Publicado: (2012)

Estradiol regulates oxidative stress and angiogenesis of myocardial microvascular endothelial cells via the CDK1/CDK2 pathway
por: Zhou, Ke, et al.
Publicado: (2023)

Second-Nearest-Neighbor Correlations from Connection of Atomic Packing Motifs in Metallic Glasses and Liquids
por: Ding, Jun, et al.
Publicado: (2015)

Elastic properties of dynein motor domain obtained from all-atom molecular dynamics simulations
por: Kamiya, Narutoshi, et al.
Publicado: (2016)

All atom NMDA receptor transmembrane domain model development and simulations in lipid bilayers and water
por: Mesbahi-Vasey, Samaneh, et al.
Publicado: (2017)

The JIL-1 Kinase Affects Telomere Expression in the Different Telomere Domains of Drosophila
por: Silva-Sousa, Rute, et al.
Publicado: (2013)

Conserved Motifs and Domains in Members of Pospiviroidae
por: Wüsthoff, Kevin-Phil, et al.
Publicado: (2022)

EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains
por: Yamamoto, Tatsuya, et al.
Publicado: (2014)

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain
por: Schmidt, Sven H., et al.
Publicado: (2019)

CDK8 as the STAT1 serine 727 kinase?
por: Staab, Julia, et al.
Publicado: (2013)

The awakening of the CDK10/Cyclin M protein kinase
por: Guen, Vincent J., et al.
Publicado: (2017)

The cryoelectron microscopy structure of the human CDK-activating kinase
por: Greber, Basil J., et al.
Publicado: (2020)

Conference on Photons, Atoms and All That
por: Marcinek, Roman, et al.
Publicado: (2002)

A new linear cyclin docking motif that mediates exclusively S‐phase CDK‐specific signaling
por: Faustova, Ilona, et al.
Publicado: (2020)

Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division
por: Cedeno-Rosario, Luis, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8nf0m9epppa4q2thq1jhip8rme