ALS-Related Mutant SOD1 Aggregates Interfere with Mitophagy by Sequestering the Autophagy Receptor Optineurin

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive demise of motor neurons. One of the causes of familial ALS is the mutation of the gene encoding superoxide dismutase 1 (SOD1), which leads to abnormal protein aggregates. How SOD1 aggregation drives A...

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Detalles Bibliográficos
Autores principales: Tak, Yeong Jin, Park, Ju-Hwang, Rhim, Hyangshuk, Kang, Seongman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590160/
https://www.ncbi.nlm.nih.gov/pubmed/33065963
http://dx.doi.org/10.3390/ijms21207525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590160/
https://www.ncbi.nlm.nih.gov/pubmed/33065963
http://dx.doi.org/10.3390/ijms21207525

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