Nonsequential Splicing Events Alter Antisense-Mediated Exon Skipping Outcome in COL7A1

The COL7A1 gene encodes homotrimer fibrils essential for anchoring dermal and epidermal layers, and pathogenic mutations in COL7A1 can cause recessive or dominant dystrophic epidermolysis bullosa. As a monogenic disease gene, COL7A1 constitutes a potential target for antisense oligomer-mediated exon...

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Detalles Bibliográficos
Autores principales: Ham, Kristin A., Aung-Htut, May Thandar, Fletcher, Sue, Wilton, Steve D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590164/
https://www.ncbi.nlm.nih.gov/pubmed/33081018
http://dx.doi.org/10.3390/ijms21207705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590164/
https://www.ncbi.nlm.nih.gov/pubmed/33081018
http://dx.doi.org/10.3390/ijms21207705

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