TLR1/2 and 5 induce elevated cytokine levels from rheumatoid arthritis monocytes independent of ACPA or RF autoantibody status

OBJECTIVE: RA is an autoimmune inflammatory joint disease. Both RF and ACPA are associated with more progressive disease and higher levels of systemic inflammation. Monocyte activation of toll-like receptors (TLRs) by endogenous ligands is a potential source of increased production of systemic cytok...

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Detalles Bibliográficos
Autores principales: Thwaites, Ryan S, Unterberger, Sarah, Chamberlain, Giselle, Walker-Bone, Karen, Davies, Kevin A, Sacre, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590412/
https://www.ncbi.nlm.nih.gov/pubmed/32594150
http://dx.doi.org/10.1093/rheumatology/keaa220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590412/
https://www.ncbi.nlm.nih.gov/pubmed/32594150
http://dx.doi.org/10.1093/rheumatology/keaa220

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