MUC1-induced immunosuppression in colon cancer can be reversed by blocking the PD1/PDL1 signaling pathway

Mucin1 (MUC1) upregulation in colon cancer has been linked to poor patient outcomes and advanced stage at diagnosis. This is partially due to MUC1-mediated inhibition of T-cell proliferation affecting efficient lysis by cytotoxic lymphocytes, which contributes to escape from immune surveillance. In...

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Detalles Bibliográficos
Autores principales: Zhang, Yinghui, Dong, Xiangqian, Bai, Liping, Shang, Xueqin, Zeng, Yujian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590440/
https://www.ncbi.nlm.nih.gov/pubmed/33133253
http://dx.doi.org/10.3892/ol.2020.12180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590440/
https://www.ncbi.nlm.nih.gov/pubmed/33133253
http://dx.doi.org/10.3892/ol.2020.12180

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