Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types

BACKGROUND: The T cell-inflamed tumor microenvironment, characterized by CD8 T cells and type I/II interferon transcripts, is an important cancer immunotherapy biomarker. Tumor mutational burden (TMB) may also dictate response, and some oncogenes (i.e., WNT/β-catenin) are known to mediate immunosupp...

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Detalles Bibliográficos
Autores principales: Bao, Riyue, Stapor, Daniel, Luke, Jason J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590690/
https://www.ncbi.nlm.nih.gov/pubmed/33106165
http://dx.doi.org/10.1186/s13073-020-00787-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590690/
https://www.ncbi.nlm.nih.gov/pubmed/33106165
http://dx.doi.org/10.1186/s13073-020-00787-6

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