Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen

Diphthamide is a unique post-translationally modified histidine residue (His(715) in all mammals) found only in eukaryotic elongation factor-2 (eEF-2). The biosynthesis of diphthamide represents one of the most complex modifications, executed by protein factors conserved from yeast to humans. Diphth...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Zuo, Zehua, Zou, Meijuan, Finkel, Toren, Liu, Shihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591051/
https://www.ncbi.nlm.nih.gov/pubmed/33057331
http://dx.doi.org/10.1371/journal.pgen.1009068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591051/
https://www.ncbi.nlm.nih.gov/pubmed/33057331
http://dx.doi.org/10.1371/journal.pgen.1009068

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