LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay

PURPOSE: Tandutinib (MLN518 or CT 53518) (TND) is a novel, oral, small-molecule inhibitor of type III receptor tyrosine kinases utilized for the treatment of acute myeloid leukemia (AML). MATERIALS AND METHODS: In silico prediction of hepatic drug metabolism for TND was determined using the StarDrop...

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Detalles Bibliográficos
Autores principales: Attwa, Mohamed W, Abdelhameed, Ali S, Al-Shakliah, Nasser S, Kadi, Adnan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591096/
https://www.ncbi.nlm.nih.gov/pubmed/33122888
http://dx.doi.org/10.2147/DDDT.S274118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591096/
https://www.ncbi.nlm.nih.gov/pubmed/33122888
http://dx.doi.org/10.2147/DDDT.S274118

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