Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway

New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived from Asians, to identify genetic vulnerabilities that can be explored as therapeutic targets. We identify known and novel fitness...

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Detalles Bibliográficos
Autores principales: Chai, Annie Wai Yeeng, Yee, Pei San, Price, Stacey, Yee, Shi Mun, Lee, Hui Mei, Tiong, Vivian KH, Gonçalves, Emanuel, Behan, Fiona M, Bateson, Jessica, Gilbert, James, Tan, Aik Choon, McDermott, Ultan, Garnett, Mathew J, Cheong, Sok Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591259/
https://www.ncbi.nlm.nih.gov/pubmed/32990596
http://dx.doi.org/10.7554/eLife.57761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591259/
https://www.ncbi.nlm.nih.gov/pubmed/32990596
http://dx.doi.org/10.7554/eLife.57761

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